The EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium is a consortium of pregnancy and birth cohorts that aims to collaborate to investigate the genetic basis of phenotypes in antenatal and early life and childhood.
EAGLE covers a broad range of pathways and phenotypes, and will integrate closely with the DOHaD (developmental origins of health and disease) community.
Genetic study of childhood anxiety and depression
A genome-wide association study of childhood internalising symptoms by the EAGLE consortium was recently published in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). The study sheds light on the genetic architecture of early symptoms of depression and anxiety and reveals genetic overlap between childhood and adult mental health disorders. Christel Middeldorp, professor of Child & Youth Psychiatry at the University of Queensland said, “These findings are important because they help identify people most at risk of symptoms continuing across the lifespan, so intense treatment can be provided where needed.” Professor Middeldorp further highlights the results of this work in a press release published by the University of Queensland. (25 May 2022)